I use space for item 1 and mouse buttons for the rest

Item 1 : 1
Item 2 : 2
Item 3 : 3
Item 4 : 4
Item 5 : 5
Item 6 : 6

Neutral abilty 1 : Q
Neutral abilty 2 : W

Control hero : F1
Control Courier : F2
Deliver items : F
Learn abilty : O
Learn Stats : U


Attack : A
Stop : S
Hold : H
Etc...

Scoreboard : /
Voice : ,

legacy keys FTW from old school dota.

I wish i could put deny on my scroll wheel apart from that normal except space for item 1

Items are basic QWER and DF. For items there 2 buttons on my mouse, space and then 3, 4 and 5.

my item in SPACE and Q
so 123 skills and ulti is WERT, other skills in FG
Hope it helps

Item 1: Alt+Q
Item 2: Alt+W
Item 3: Alt+E
Item 4: Alt+A
Item 5: Alt+ S
Item 6: Alt+D

That's mine

1-6 for items and qwerdf for skills

i'm still looking for the best to me... for now

skills: 1,2,3,4,r,t
items: z,x,c,v,g,h
attack: a
stop: s
hold: f

Control hero: |
Control courier: space
Control group: tab

I didnt like the hotkeys in dota1 since ur fingers have to be so confused so u can play quick and good and besise the thing that sucked the most is equiping items from Num keys 7,8,9,4,5,6 that sucked also and when i first played HoN hotkeys were verry verry simple Q,W,E,R,D,F and for items Alt-Q , ALt-W , Alt-E , Alt-A , Alt-S , Alt-D well those suit me well and i did the same in dota 2 i mean i configured it that way and i dont usually use self cast abilityes cuz i play enough fast so i dont really think that it would hlp me in somehting SPACE for cour C for auto take items from stash N for buying Tp scroll Shift-click for making sticky and X for auto purchaise stiky items

Items:
1 - Space
2 - c
3 - x
4 - v
5 - t
6 - g

QWER - DF
level up - 2
Attribute - 3

Chat wheel:
Missing - z
Top/mid/bot - Alt + 2/3/4

Get Back/Care - Alt + A/S

i hope a get a mouse with buttons.